Relationship of extracellular vesicles with the spread of cancer
Keywords:
vesículas extracelulares, exosomas, MicroRNAs, biomarcadorAbstract
Background: extracellular vesicles are essential membranous structures for intercellular communication; they travel in body fluids and deliver messages to cells of the organism. This transmission occurs through the release of different substances and it is associated with different normal and pathological physiological conditions such as cancer. Cancer is a disease with a multifactorial cause of high incidence and mortality, which constitutes a serious health problem and a challenge for health services, making it essential to carry out studies related to the search of diagnostic and therapeutic alternatives.
Objective: to substantiate the relationship between the spread of cancer and extracellular vesicles.
Methods: an updated bibliographic review was carried out using the resources available in Infomed. 25 articles were consulted, of which 72 % is of the last 5 years. The methods used were analysis-synthesis, induction-deduction and historical-logical.
Development: the relationship between extracellular vesicles and cancer spread was based on the description of their structural and functional characteristics and their bioactive molecules´ content. In addition, the use of extracellular vesicles derived from tumor cells as biomarkers was analyzed.
Conclusions: extracellular vesicles were identified as versatile vehicles that have a content rich in various substances. It was found that tumor cells secrete vesicles to recruit other cell lines and promote their development, and that microRNA are part of the bioactive molecular content, which is attributed an essential role in all stages of cancer development, in addition to these vesicles are considered ideal biomarkers for cancer diagnosis, evaluation and treatment.
DeCS: EXTRACELLULAR VESICLES/physiology; NEOPLASMS/diagnosis; BIOMARKERS, TUMOR/therapeutic use; MicroRNAs; EXOSOMES.
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References
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